Has this problem occurred with other Steam games, or other programs on your computer?
Have you verified that you are using the latest Asus drivers?
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I'm having the same issue - if I play music outside the game in the background, or after the game has finished, I experience a distortion sometimes. This only started after I started playing the game, and I've tried shutting down all other programs but it persists until reboot. I think FTL is doing something to some of our soundcards!
Forum janitor — If you spot spam, PM me the URL and/or the username of the spammer. I have powers, moderator powers. I am not keen on using them, but will do so if needed.